people having thalassemia already have red blood cells with like a hard and sticky irregular shape
I hypothesized that people having thalassemia already have red blood cells with like a hard and sticky irregular shape. Their blood cells do not really meet their body needs in early childhood or early adulthood. Furthermore, the bone marrow gets weak as well as its ability to produce cells reduces after a certain age. As a result parts of the brain might damage leading to Alzheimer’ disease. Now, the research paper is going to talk about whether Beta-thalassemia is or is not associated with Alzheimer disease. We want to investigate this hypothesis whether is right or wrong.
References must be used:
We are going to use the reference below, plus 5 other (Scholarly) journals from your choice. Only scholarly journals are acceptable. The reference style must be American Psychological Association (APA).
1. Elsayh K, Zahran A, El-Abaseri T, Mohamed A, El-Metwally T. Hypoxia biomarkers, oxidative stress, and circulating microparticles in pediatric patients with thalassemia in Upper Egypt. Clinical And Applied Thrombosis/Hemostasis: Official Journal Of The International Academy Of Clinical And Applied Thrombosis/Hemostasis 2014;20:536-545.
2. Nemtsas P, Arnaoutoglou M, Perifanis V, Koutsouraki E, Orologas A. Neurological complications of beta-thalassemia. Annals Of Hematology 2015;94:1261-1265.
3. Shehata G, Elsayh K, Mohamed A, Rageh T, Rafet N. Cognitive function and event related potentials in children with beta-thalassemia. Journal Of Pediatric Neurology 2010;8:187-192.
4. Chen G, Xu J, Lahousse S, Caggiano N, de la Monte S. Transient hypoxia causes Alzheimer-type molecular and biochemical abnormalities in cortical neurons: Potential strategies for neuroprotection. Journal Of Alzheimer’s Disease 2003;5:209-228.
5. Jain M, Bagul A, Porwal A. Psychosocial problems in thalassemic adolescents and young adults. Chronicles Of Young Scientists 2013;4:21-23.